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KMID : 0604219950020010099
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Korean Journal Investigative Dermatology
1995 Volume.2 No. 1 p.99 ~ p.108
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Clinical and Histopathologic Observations on Nevus Sebaceus of
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Abstract
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Nevus sebaceus of Jadassohn has been referred to as a organoid nevus that classically evolves through several stages and may be associated with a range of skin tumors. This study was performed to evaiuate the clinical and histopathologic findings
of
nevus sebaceus of Jadassohn by age group.
We reviewed clinical informations and histopathologic findings of 51 patients who were diagnosed with nevus sebaceus of Jadassohn.
@ES The results were as follows:
@EN 1. Clinical findings
1) Among 51 cases of nevus sebaceus. 30 were male and 21 female. With sexual ration of a 1.4:1. Thirty cases(58%) visited at their age of 2nd decade.
2) The lesions were present at birth in 29 of 41 cases(71%).
3) The most commonly affected area was the scalp(78%). The rest of the lesions (22%) developed on the face.
4) Most of the lesions showed verrucous or nodular configuration. While in the age group of first decade, 5 of 9 cases (56) showed smooth surfaced lesions
2. Histopathologic findings
1) Epidermis: Hyperkeratosis (67%). Papillomatosis (86%) and acanthosis (84%) were noted in all age groups but marked epidermal changes predominated in the age groups over 10 years old.
2) Dermal inflammatory cell infiltrate only in the age group over 10 years old.
3) Skin appendages: The apparent proliferation of sebaceous glands was noted in 28 of 51 cases (55%0 and more prominent in the age group over 10 years old. Mature hair follicles were noted in 18 of 51 cases (35%) who belonged to the age group
over
10n
years old. Apocrine glands were observed in 25 cases (4950.
4) Secondary tumors: A case of nevus sebaceus was associated with basal cell epithelioma and sebaceous epithelioma, and 2 cases associated with apocrine cystadenoma.
In childhood, sebaceous glands and hair structures are underdeveloped for the most part and papillomatous epidermal hyperplasia is not prominent. In adolescence, the majority of cases show massive development of sebaceous glands and mature hair
follicles with papillomatous epidermal hyperplasia. In adulthood, sebaceous glands are enlarged but hair structures are immature for the most part. Apocrine glands were observed in 25 of 51 cases.
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KEYWORD
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